What Are Growth Factors In Skincare?

Frequently Asked Questions

Growth factors are signaling proteins naturally produced by the body that communicate with skin cells, prompting them to produce collagen, elastin, and other structural components of the extracellular matrix. In skincare, they are formulated into serums to compensate for the decline in the body's own growth factor production that occurs with age. Different growth factor types have different cellular targets – which is why multi-growth-factor formulations like ZO's are more comprehensive than single-growth-factor products.

Clinical evidence supports their efficacy when formulated at effective concentrations and with appropriate delivery mechanisms. In ZO's 2026 independent clinical study, 100% of subjects agreed their skin looked lifted and supported after 12 weeks, with measurable improvements in skin thickness and elasticity confirmed by instrumental measurement. Results require consistent use over 8–12 weeks; growth factors work at a structural level and are not a rapid-visible-effect ingredient.

Meaningful results begin to emerge at 8 weeks in clinical studies, with structural improvements – skin thickness, elasticity, and visible firmness – continuing to develop through week 12. Surface improvements such as texture and radiance may be perceived sooner. Consistent AM and PM use is required to maintain the cumulative effect.

Yes. Growth factor serums do not exfoliate, do not increase photosensitivity, and do not strip the barrier. They are generally well-tolerated across all skin types, including sensitized skin. ZO's Growth Factor Serum clinical study included participants across Fitzpatrick skin types II–VI. For skin that is actively sensitized or in a compromised state, physician guidance on timing and system integration is recommended before introducing any new serum.